Dose-related cutaneous toxicities with etoposide

✍ Scribed by Christopher P. Murphy; Elizabeth A. Harden; Roger H. Herzig

• Book ID: 101331217
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 251 KB
• Volume: 71
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19930515)71:10<3153::aid-cncr2820711042>3.0.co;2-#

✦ Synopsis

Background. Cutaneous toxicities are seen frequently in association with administration of high doses, but not standard doses, of agents. With the increasing use of etoposide in dose-intensive regimens, cutaneous toxicities are appearing with increasing frequency.

A retrospective analysis of 145 patients treated with various doses of etoposide was conducted. This analysis revealed a statistically significant increase in the frequency of these toxicities at doses of 2400 mg/m2 and 4200 mg/mz, compared with doses of 1800 mg/rnz. Intense, painful palmar erythema accompanied by bullae formation and desquamation occurred at the 4200 mg/mz dose. Symptoms were controlled by a short course of corticosteroids.

Although they are not dose limiting, substantial dose-related skin toxicities can be an important side effect of high-dose etoposide therapy. Cancer Methods.

Results.

Conclusion.