Dose-ranging antiemetic evaluation of th
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Lorraine Baltzer; Mark G. Kris; Leslie B. Tyson; James R. Rigas; Katherine M. W.
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Article
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1993
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John Wiley and Sons
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English
โ 484 KB
Background. RG 12915 is a potent, selective 5-HT3 receptor antagonist with a biologic half-life of 31-20 hours. RG 12915 prevents cisplatin-induced emesis in ferrets at doses of 0.03 mg/kg. Animal toxicology studies permitted safe testing in humans at doses of up to 2.0 mg/kg. This dose-ranging tria