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Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy

โœ Scribed by Stefan C. Grant; Mark G. Kris; Richard J. Gralla; Rebecca A. Clark; Leslie B. Tyson


Publisher
Springer
Year
1993
Tongue
English
Weight
314 KB
Volume
31
Category
Article
ISSN
0344-5704

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Background. RG 12915 is a potent, selective 5-HT3 receptor antagonist with a biologic half-life of 31-20 hours. RG 12915 prevents cisplatin-induced emesis in ferrets at doses of 0.03 mg/kg. Animal toxicology studies permitted safe testing in humans at doses of up to 2.0 mg/kg. This dose-ranging tria