Cefuroxime axetil is an ester pro-drug which permits the oral administration of cefuroxime. This study was designed to evaluate the dose proportionality of four different doses administered after a meal and to determine the absolute bioavailability of cefuroxime axetil administered with and without
Dose effects of the food spice cardamom on aspects of hamster gut physiology
✍ Scribed by Ya-Ling Huang; Gow-Chin Yen; Fuu Sheu; Jin-Yuarn Lin; Chi-Fai Chau
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 207 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1613-4125
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The dose effects of pectic polysaccharide‐rich extract from the food spice cardamom (Amomum villosum Lour.) on intestinal environment were investigated. The results showed that pectic polysaccharides and hemicellulose were the major polysaccharides in the cardamom extract. The administration of cardamom extract (0.5 and 1.5 g/100 g diet) effectively (p < 0.05) shortened hamster gastrointestinal transit time by ∼︁ 58%, increased fecal moisture contents (148–174%), increased SCFA concentrations in hindgut (4.0‐ to 7.8‐fold), decreased the activities of β‐D‐glucuronidase (by 71.4–85.7%), β‐D‐glucosidase (by 24.3–51.5%), mucinase (by 63.6–72.7%), and urease (by 88.8–90.4%) in feces, and reduced the production of toxic ammonia (by 16.1–64.5%). These findings suggested that the consumption of cardamom extract (at least 0.5 g/100 g diet or 40 mg/day) might exert a favorable effect on improving the gastrointestinal milieu, and also provide a clue to substantiate its traditional therapeutic uses and dosage for intestinal health improvement.
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