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Dose dependent enzyme induction by oxcarbazepine?

✍ Scribed by P. N. Patsalos; J. M. Zakrzewska; A. A. Elyas

Publisher
Springer
Year
1990
Tongue
English
Weight
192 KB
Volume
39
Category
Article
ISSN
0031-6970

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✦ Synopsis

Antipyrine half life and clearance was compared in four patients with classical idiopathic trigeminal neuralgia during carbamazepine (CBZ) or CBZ/phenytoin (PHT) and after substitution with oxcarbazepine (OXC) monotherapy. OXC is observed to be less of a hepatic enzyme inducer than CBZ or CBZ/PHT in combination, however induction by OXC may be dose related.

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