Dose-dependent induction of anti–native dna antibodies in cats by propylthiouracil

✍ Scribed by David P. Aucoin; Robert L. Rubin; Mark E. Peterson; Marcus M. Reidenberg; Dennis E. Drayer; Arthur I. Hurvitz; Robert G. Lahita

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 492 KB
• Volume: 31
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780310517

✦ Synopsis

Cats receiving propylthiouracil (PTU) develop antinuclear antibodies (ANA) and an immune-mediated disease syndrome characterized by anorexia, lymphadenopathy, weight loss, and Coombs-positive hemolytic anemia. Investigation of the ANA specificity indicated that the predominant ANA activity consisted of anti-native DNA (nDNA) antibodies. The formation of anti-nDNA antibodies and immune-mediated disease syndrome appeared to be dose-dependent, even in cats in which a response had been induced on 4 prior occasions. These results supply further evidence that PTU-induced autoimmunity is not the result of a simple drug allergy. Rather, it appears that PTU induces a lupus-like syndrome, including the hallmark sign of systemic lupus erythematosus, anti-nDNA antibodies.

More than 25 drugs have been implicated as causes of antinuclear antibodies (ANA) and druginduced lupus-like syndromes in humans (1,2). Studies