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Dose-dependency of 2-acetylaminofluorene binding to liver DNA and hemoglobin in mice and rats

โœ Scribed by Michael A. Pereira; Luan-Ho C. Lin; Lina W. Chang

Book ID
113205680
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
608 KB
Volume
60
Category
Article
ISSN
0041-008X

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The binding of reactive metabolites of the carcinogenN-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: Effects of glutathione and methionine
โœ Meerman, John H. N. ;Tijdens, Roeline B. ;Mulder, Gerard J. ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 580 KB

The covalent binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated, intact rat liver nuclei was studied. The chemically synthesized 2-acetylaminofluorene-N-sulfate became covalently bound to DNA and protein to form adducts, 50% to 60% of whi