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Dose- and treatment duration-dependence of ganciclovir against murine cytomegalovirus infection in severe combined immunodeficient mice—experimental and clinical implications

✍ Scribed by J. Duan; W. Paris; P. Kibler; C. Bousquet; M. Liuzzi; M.G. Cordingley


Book ID
114145107
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
116 KB
Volume
34
Category
Article
ISSN
0166-3542

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## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)‐1‐(3‐hydroxy‐2‐pho