Dose and sex-dependent disposition of ketoconazole in rats
✍ Scribed by Per Sjöberg; Lena Ekman; Thomas Lundqvist
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 409 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The pharmacokinetics of cyclosporin A (CyA) were investigated in the rat following intravenous doses of 1.7, 3 . 3 , and 6-4mg kg-' and oral doses of 3.1, 6.8, and 12.9 mg kg-I . The blood concentration-time profile after intravenous administration was adequately described by a twocompartment model
Mean minimum quantifiable level (MQL) was 0.01 K g / g . \* No sample.
## Abstract The pharmacokinetics and relative systemic availability or oral propranolol were studied in three healthy volunteers following administration of 10, 40, and 80 mg of propranolol hydrochloride. Plasma concentrations of propranolol were determined using a sensitive and specific fluorometr
Dose-dependency in local disposition of 5-fluorouracil (5-FU) was evaluated using the rat liver in the once-through perfusion system under the non-steady-state condition. A curve-fitting program based on Finite Element Method, MULTI(FEM), was adopted to evaluate the capacity-limited elimination in t