Dosage form design for improvement of bioavailability of levodopa III: Influence of dose on pharmacokinetic behavior of levodopa in dogs and parkinsonian patients
โ Scribed by Kunihiro Sasahara; Takashi Nitanai; Taeko Habara; Tadashi Morioka; Eiichi Nakajima
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 564 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
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Plasma levels of levodopa, total dopamine, and residual amounts of levodopa and its metabolites at the administered site were analyzed following administration of single 100-mg doses of levodopa in solution into isolated segments of the duodenum, jejunum, and ileum of the dog. The largest area under