Several potential mechanisms for reduced levodopa bioavailability following oral administration to dogs and humans were investigated by studying the influence of the administration route on plasma levodopa levels after intravenous, hepatoportal, and duodenal administrations to dogs. The observed ave
โฆ LIBER โฆ
Dosage form design for improvement of bioavailability of levodopa VI: Formulation of effervescent enteric-coated tablets
โ Scribed by Kenji Nishimura; Kunihiro Sasahara; Mikio Arai; Takashi Nitanai; Yoshihiko Ikegami; Tadashi Morioka; Eiichi Nakajima
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 488 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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Plasma levels of levodopa, total dopamine, and residual amounts of levodopa and its metabolites at the administered site were analyzed following administration of single 100-mg doses of levodopa in solution into isolated segments of the duodenum, jejunum, and ileum of the dog. The largest area under