Dopamine modulates a Ca2+-activated potassium conductance in mammalian hippocampal pyramidal cells
β Scribed by Benardo, Larry S.; Prince, David A.
- Book ID
- 109726358
- Publisher
- Nature Publishing Group
- Year
- 1982
- Tongue
- English
- Weight
- 472 KB
- Volume
- 297
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/297076a0
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π SIMILAR VOLUMES
Calcium currents in CA1 neurons from rat hippocampus were studied with the whole-cell, patch-clamp technique. Under control conditions high-voltage-activated (HVA) calcium currents activated from membrane potentials of -80 mV and -40 mV underwent "run-down". The rate of run-down of the current activ
In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 microM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on b