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Dopamine D4 receptors elevated in schizophrenia

✍ Scribed by Seeman, Philip; Guan, Hong-Chang; Van Tol, Hubert H. M.

Book ID
109785415
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
781 KB
Volume
365
Category
Article
ISSN
0028-0836

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The pur.pose of this study was to determine whether dopamine D4 receptors could be detected in the human brain striatum by means of an indirect ligandbinding method, because no dopamine 114 receptor-selective ligand presently exists. The antipsychotic clozapine is more selective for the dopamine D4

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The dopamine D4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (DRD4). Although several genetic linkage analyses performed on schizophrenia multiplex families from different