Dopamine D2/D3 receptors modulate cocaine’s reinforcing and discriminative stimulus effects in rhesus monkeys
✍ Scribed by Rachna S Sinnott; Robert H Mach; Michael A Nader
- Book ID
- 117512642
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 232 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0376-8716
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The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D 2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthan
To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted