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Dopamine D 1 /D 5 Receptor Antagonists with Improved Pharmacokinetics: Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of Benzazepine D 1 /D 5 Antagonists

✍ Scribed by Wu, Wen-Lian; Burnett, Duane A.; Spring, Richard; Greenlee, William J.; Smith, Michelle; Favreau, Leonard; Fawzi, Ahmad; Zhang, Hongtao; Lachowicz, Jean E.


Book ID
120471604
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
262 KB
Volume
48
Category
Article
ISSN
0022-2623

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## Abstract Syntheses of labelled versions of 5‐HT~3~ receptor antagonists, Alosetron and Lurosetron, are described. [^14^C]Alosetron was prepared by routes utilizing either Fischer indolisation of an amidohydrazine or palladium‐mediated cyclisation of an aryl enaminone as key steps. ^2^H and ^13^C