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Donor-specific transfusion-induced tolerance: mechanisms revisited

✍ Scribed by J.-P Soulillou


Book ID
117236516
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
122 KB
Volume
30
Category
Article
ISSN
0041-1345

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Donor-specific tolerance to heart allograft was induced in adult Lewis rats by pregraft donorspecific blood transfusion (DST). We previously showed that this tolerant state is characterized by a dramatic inhibition of T cell and macrophage activation. In addition, tolerant animals could not mount an