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Transfer of “infectious” cardiac allograft tolerance induced by donor-specific transfusion

✍ Scribed by Kataoka, Masaaki; Shimizu, Yoshiaki; Margenthaler, Julie A; Landeros, Keith; Otomo, Naoki; Flye, M.Wayne

Book ID
123581992
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
72 KB
Volume
132
Category
Article
ISSN
0039-6060

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Donor-specific tolerance to heart allograft was induced in adult Lewis rats by pregraft donorspecific blood transfusion (DST). We previously showed that this tolerant state is characterized by a dramatic inhibition of T cell and macrophage activation. In addition, tolerant animals could not mount an