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Domino Reaction of 1,3-Bis(trimethylsilyloxy)-1,3-dienes with Oxalyl Chloride: General and Stereoselective Synthesis of γ-Alkylidenebutenolides

✍ Scribed by Peter Langer; Toni Schneider; Martin Stoll


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
284 KB
Volume
6
Category
Article
ISSN
0947-6539

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Regio- and Stereoselective Synthesis of
✍ Peter Langer; Martin Stoll 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB

The remarkably simple synthesis of γ-alkylidenebutenolides 3 is achieved by cyclization of the dilithiated 1,3-dicarbonyl compounds 1 with N,N'-dimethoxy-N,N'-dimethylethanediamide (2). This regio- and stereoselective cyclization provides a route to a wide range of butenolides, which are of pharmaco