✦ LIBER ✦

Domino liver transplantation for familial amyloid polyneuropathy

✍ Scribed by Hemming, Alan W. ;Cattral, Mark S. ;Chari, Ravi S. ;Greig, Paul D. ;Lilly, Leslie B. ;Ashby, Peter ;Levy, Gary A.

Publisher: Wiley (John Wiley & Sons)
Year: 1998
Tongue: English
Weight: 64 KB
Volume: 4
Category: Article
ISSN: 1074-3022
DOI: 10.1002/lt.500040303

No coin nor oath required. For personal study only.

✦ Synopsis

Familial amyloid polyneuropathy is an autosomal dominant disorder in which the liver produces a variant prealbumin that is deposited along nerves, leading to a progressive and fatal polyneuropathy that begins in the third decade of life. Liver transplantation has been the only successful treatment to date. Apart from the production of the variant protein, there are no other abnormalities in these amyloid livers. We describe two cases in which, at the time of transplantation, the amyloid livers were subsequently used for transplantation in another patient, and we discuss the implications.

📜 SIMILAR VOLUMES

Clinical improvement after liver transpl

Clinical improvement after liver transplantation for type I familial amyloid polyneuropathy

✍ Professor P. Parrilla; P. Ramirez; F. S. Bueno; R. Robles; F. Acosta; M. Miras; 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB

Transthyretin-derived amyloid deposition

Transthyretin-derived amyloid deposition on the gastric mucosa in domino recipients of familial amyloid polyneuropathy liver

✍ Yo-ichi Takei; Takahisa Gono; Masahide Yazaki; Shu-ichi Ikeda; Toshihiko Ikegami 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 1 views

Familial amyloid polyneuropathy (FAP) is a form of hereditary generalized amyloidosis. Liver tissue explanted from FAP patients has normal structure and function, except for the production of amyloidogenic variant transthyretin (TTR), and domino liver transplantation (DLT) using grafts from FAP pati

Liver transplantation and combined liver

Liver transplantation and combined liver-heart transplantation in patients with familial amyloid polyneuropathy: A single-center experience

✍ Ana-Paula Barreiros; Felix Post; Maria Hoppe-Lotichius; Reinhold P. Linke; Chris 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB

Liver transplantation (LT) is the only curative option for patients with familial amyloid polyneuropathy (FAP) at present. Twenty patients with FAP underwent LT between May 1998 and June 2007. Transthyretin mutations included predominantly the Val30Met mutation but also 10 other mutations. Seven pat

The influence of the explant technique o

The influence of the explant technique on the hemodynamic profile during sequential domino liver transplantation in familial amyloid polyneuropathy patients

✍ Bibiana Escobar; Pilar Taura; Nelson Barreneche; Joan Beltran; Jaume Balust; Gra 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

Familial amyloidotic polyneuropathy (FAP) patients present adrenergic cardiac input blockade secondary to amyloid deposits and sympathetic neuropathy. Consequently, their capacity to compensate for hemodynamic changes is limited. To avoid hemodynamic disturbances in sequential liver transplants, a s

Domino transplantation using livers from

Domino transplantation using livers from patients with familial amyloidotic polyneuropathy: Should we halt?

✍ Bo-Göran Ericzon 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB

Liver transplantation for familial amylo

Liver transplantation for familial amyloidotic polyneuropathy: Impact on Swedish patients' survival

✍ Sadahisa Okamoto; Jonas Wixner; Konen Obayashi; Yukio Ando; Bo-Göran Ericzon; St 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

Liver transplantation (LTx) for familial amyloidotic polyneuropathy (FAP) is an accepted treatment for this fatal disease. However, the long-term outcome with respect to that of nontransplanted patients has not been fully elucidated. The aim of this study was to compare the long-term survival of Swe