Familial amyloid polyneuropathy is an autosomal dominant disorder in which the liver produces a variant prealbumin that is deposited along nerves, leading to a progressive and fatal polyneuropathy that begins in the third decade of life. Liver transplantation has been the only successful treatment t
Clinical improvement after liver transplantation for type I familial amyloid polyneuropathy
β Scribed by Professor P. Parrilla; P. Ramirez; F. S. Bueno; R. Robles; F. Acosta; M. Miras; J. A. Pons; F. L. Andreu; M. Munar-Ques
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 428 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-1323
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Transthyretin amyloid polyneuropathy, caused by mutations in the transthyretin gene, is a progressive condition for which liver transplantation is an established treatment. Favorable outcomes have been described in patients with the most common transthyretin mutation, Val30Met, but outcomes have bee