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Does PTH have a direct effect on intestine?

✍ Scribed by I. Nemere; D. Larsson

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
93 KB
Volume
86
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. However, diverse laboratories have each provided some evidence to suggest PTH does indeed have a direct effect on intestine. We will briefly review the evidence for biological effects, biochemical effects, and the presence of intestinal receptors for PTH, and conclude with the implications for biomedical research.

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