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Response to clomipramine after short cou

Response to clomipramine after short course of lithium in treatment-resistant depression: Does lithium have a ‘priming’ effect?

✍ Leo P. W. Chiu; Ranan Rimon 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB

A patient with a treatment-resistant depression of 15 months duration is reported. Initially he showed no response to clomipramine 150mg daily for 1 month. When lithium carbonate 600mg daily was added for 4 days he developed signs of lithium intoxication: drowsiness, confusion, and dystonia. After l