The role of haem in the activity of chlo
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Timothy J. Egan; Helder M. Marques
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Article
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1999
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Elsevier Science
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English
β 504 KB
Advances made over the last decade indicate that the mechanism of action of important antimalarial agents, such as chloroquine, involves formation of p -p complexes between drugs and ferriprotoporphyrin IX. This process is believed to block the detoxification of host haemoglobin-derived haem in the