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Does midazolam inhibit the development of acute tolerance to the analgesic effect of alfentanil?

✍ Scribed by Igor Kissin; Pamela T. Brown; Edwin L. Bradley Jr.

Book ID
118346023
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
410 KB
Volume
52
Category
Article
ISSN
0024-3205

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## Abstract The effect on digit‐symbol substitution (DSST) of duration and extent of exposure to midazolam was studied in seven healthy male volunteers. Individual pharmacokinetic and pharmacodynamic parameters were estimated after a 7Β·5 mg intravenous bolus dose of midazolam. Subjects then receive