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Development of acute tolerance to the cardiorespiratory effects of alfentanil after subsequent bolus injection in conscious rats

✍ Scribed by Brian M. Doorley; Valerie V. Knight; Theodore C. Spaulding


Book ID
118342902
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
455 KB
Volume
43
Category
Article
ISSN
0024-3205

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Furosemide was given to rats as five different i.v. bolus doses (2.5-100mg kg-I), or as an i.v. infusion to a steady-state concentration in plasma of 14pgml-'. The urinary furosemide excretion rate (AAe/At) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion-re