Acute tolerance development to the diure
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Dr. Margareta Hammarlund; Lennart K. Paalzow
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Article
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1985
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John Wiley and Sons
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English
β 607 KB
Furosemide was given to rats as five different i.v. bolus doses (2.5-100mg kg-I), or as an i.v. infusion to a steady-state concentration in plasma of 14pgml-'. The urinary furosemide excretion rate (AAe/At) and the diuretic effect (volume of urine) were measured. A parallel shift in the excretion-re