Does genomic imprinting contribute to valproic acid teratogenicity?☆
✍ Scribed by Sidney L. Beck
- Book ID
- 114273710
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 62 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0890-6238
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1
The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. Treatment of pregnant dams (600 mg/kg sodium valproate in distilled water, i.p.) during