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Does a placebo-effect exist in clinical trials on multiple sclerosis? Review of the literature

✍ Scribed by L. La Mantia; M. Eoli; A. Salmaggi; C. Milanese


Publisher
Springer Milan
Year
1996
Tongue
English
Weight
450 KB
Volume
17
Category
Article
ISSN
1590-1874

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The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the tr

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## Abstract Several studies have evaluated the impact of low dose statin (20–80 mg/day) on bone metabolism with inconclusive results despite promising data of preclinical studies. In this study, we investigated the effect of high dose simvastatin (HD‐Sim) on biochemical markers of bone turnover and