The PRISMS (Prevention of Relapses and Disability by Interferon-1a Subcutaneously in Multiple Sclerosis) trial was a doubleblind, randomized, multicenter, phase III, placebo-controlled study of interferon-1a in 560 patients from 22 centers in 9 countries with clinically definite or laboratory-supp
✦ LIBER ✦
Effect of interferon-β1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: Results of a European multicenter, randomized, double-blind, placebo-controlled trial
✍ Scribed by D. H. Miller; P. D. Molyneux; G. J. Barker; D. G. MacManus; I. F. Moseley; K. Wagner
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 163 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0364-5134
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## Abstract ## Objective Rituximab, a monoclonal antibody selectively depleting CD20+ B cells, has demonstrated efficacy in reducing disease activity in relapsing‐remitting multiple sclerosis (MS). We evaluated rituximab in adults with primary progressive MS (PPMS) through 96 weeks and safety thro