## Abstract ## Background Trial TAX 324 showed that induction chemotherapy with docetaxel plus cisplatin and 5โfluorouracil (TPF) compared with cisplatin and 5โfluorouracil (PF) followed by chemoradiation increases survival and time to progression in squamous cell carcinoma of head and neck (SCCHN
Docetaxel induction therapy in locally advanced squamous cell carcinoma of the head and neck
โ Scribed by Posner, M R; Lefebvre, J L
- Book ID
- 109997443
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 108 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ## Background. Induction chemotherapy may contribute to decreased local and distant recurrences in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) resectable for cure. ## Methods. Patients with previously untreated locally advanced stage IIIโIV (N0
## Abstract Head and neck cancer is a challenging disease that is expected to account for greater than 500,000 new cases worldwide in 2008. Toxicity has impeded advances in chemotherapy and radiation for head and neck cancer, and the prognosis for patients with recurrent and/or metastatic disease r
## Abstract ## BACKGROUND The authors conducted a series of four Phase IโII trials of highโdose and intermediateโdose docetaxel, cisplatin, and 5โfluorouracil (TPF)โbased induction chemotherapy for patients with advanced squamous cell carcinoma of the head and neck (SCCHN). The chemotherapy regime