## Abstract Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatinβsensitive SCC cell lines (Saβ3, Hβ1 and KB) and
Docetaxel Associated Pathways in Cisplatin Resistant Head and Neck Squamous Cell Carcinoma: A Pilot Study
β Scribed by George H. Yoo; Ho-Sheng Lin; Andrew J. Iskander; Marie P. Piechocki; Jeffery Oliver; Danny Kewson; Fulvio Lonardo; Michael A. Tainsky; Hyeong-Reh Kim; Harold Kim; John F. Ensley
- Book ID
- 110087833
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 521 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0023-852X
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## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##
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