Do ribosomes regulate mitochondrial RNA synthesis?
โ Scribed by Howard T. Jacobs
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 931 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
โฆ Synopsis
The levels of different classes of mitochondrially encoded transcripts are decelopmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. Z propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or posttranscriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other systems.
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