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Transcriptional regulation of mammalian ribosomal RNA genes

✍ Scribed by Masami Muramatsu

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
342 KB
Volume
3
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Eukaryotic genes are divided into three categories according to the machineries by which they are transcribed. Ribosomal RNA genes (rDNA) are the only ones that are transcribed by RNA polymerase Iand are under diflerent control from other genes transcribed by RNA polymerase 11 or III. None the less, the regulation of rDNA is of prime interest in view of its close relationship to cell growth and differentiation. In this review I shall discuss the recent progress in the study of transcription mechanisms of rDNA by

the RNA polymerase I system. The structure of the rDNA promoter and the presence of possible upstream enhancer regions will be described. In addition, factors involved in the transcription initiation of this gene will be discussed with special reference to the formation of an initiation complex.

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