Do macrophages participate in mesangial cell proliferation?
β Scribed by Gregory H TESCH; David J NIKOLIC-PATERSON; Hui Y LAN
- Book ID
- 108958476
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 904 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1320-5358
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Department of Medicine, Long lsland lewish Medical Center, New t-lvde Park, NY 71042, and [he Albert E~nstcin College of Medicine, Bronx, N Y 10467 Macrophages may modulate mesangial expansion following renal injury via secretory products. We undertook the prescnt study to determine the effects of
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## Abstract **Background:** The bioactive sphingolipid sphingosine 1βphosphate (S1P) is formed by the activation of sphingosine kinase (SPHK) in diverse stimuli, such as plateletβderived growth factor (PDGF). S1P acts not only as an extracellular mediator but also as an intracellular second messeng