Do histocompatibility antigens antigence influence the risk of head and neck carcinoma?
β Scribed by John R. Houck; Paula J. Romano; May Bartholomew; Philip J. Smith; Francine Kloszewski; Elliot S. Vesell
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 463 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0008-543X
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Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and
## Abstract The risk association between tobacco and alcohol use with squamous cell carcinoma of the head and neck (SCCHN) is well recognized. However, clearly not all individuals who smoke or drink develop SCCHN. Individual genetic susceptibility differences in carcinogenβmetabolizing enzyme funct
## Background: Serine proteases have important roles in tumor invasion and metastasis, and their inhibitors, serine protease inhibitors (serpins), are attractive targets for therapeutic strategies. on chromosome 18q21, there is a cluster of serpins: maspin, headpin, and squamous cell carcinoma anti