## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
Factors that influence growth of head and neck squamous carcinoma in the soft agar cloning assay
โ Scribed by Douglas E. Mattox; Daniel D. von Hoff; Gary M. Clark; Thomas B. Aufdemorte
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 446 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Seventy-three squamous cell carcinomas arising in the head and neck region were cultured using the soft agar clonogenic system. Thirty-six (49%) demonstrated clonal growth. The cloning efficiency was variable, ranging from 0.001 % to 1.67% (median, 0.004%). Statistically significant correlations of
## Abstract ## Background and Methods. VEGF proteins and their receptors are involved in tumor vessel neoformation. The third VEGF receptor, VEGFR3 (fltโ4) is important during both blood vessel development and lymphatic vessel formation. Because HNSCC preferentially metastasizes to regional lymph
Peripheral blood lymphocytes from patients with squamous cell carcinoma (SCC) of the head and neck were studied by spontaneous lymphocyte rosette and rosette inhibition (RI) assays prior to treatment. The patients were clinically staged and the results of the assays compared with the clinical stage