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Do changes in the mechanical properties of articular cartilage promote catabolic destruction of cartilage and osteoarthritis?

✍ Scribed by Frederick H. Silver; Gino Bradica; Alfred Tria

Book ID: 116729216
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 456 KB
Volume: 23
Category: Article
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2004.08.003

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## Abstract ## Objective To investigate whether heterozygosity for a loss‐of‐function mutation in the gene encoding the α1 chain of type XI collagen (__Col11a1__) in mice (chondrodysplasia, __cho__) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mut