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Changes in the antiangiogenic properties of articular cartilage in osteoarthritis

✍ Scribed by James O. Smith; Richard O.C. Oreffo; Nicholas M.P. Clarke; Helmtrud I. Roach

Publisher
Springer Japan
Year
2003
Tongue
English
Weight
364 KB
Volume
8
Category
Article
ISSN
0949-2658

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We report the use of immunologic methods for detecting specific alterations in human osteoarthritic cartilage. Monoclonal antibodies with specificities for proteoglycans and link proteins have been used to define immunogenic sites in these molecules. We have identified 1 site in the protein core, 1