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DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

✍ Scribed by Er-Bao Bian; Cheng Huang; Tao-Tao Ma; Hui Tao; Hui Zhang; Chang Cheng; Xiong -Wen Lv; Jun Li

Book ID: 119374875
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 920 KB
Volume: 264
Category: Article
ISSN: 0041-008X
DOI: 10.1016/j.taap.2012.06.022

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## Abstract ## Background/aims Transforming growth factor β (TGFβ1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFβ1 in a cell‐free system and activated hepatic stellate cells (HSCs), and anti