Type II DNA topoisomerase activity is required to change DNA topology. It is important in the relaxation of DNA supercoils generated by cellular processes, such as transcription and replication, and it is essential for the condensation of chromosomes and their segregation during mitosis. In mammals
โฆ LIBER โฆ
DNA topoisomerases in eukaryotes
โ Scribed by SAAVEDRA, RAUL A.; HUBERMAN, JOEL A.
- Book ID
- 109741095
- Publisher
- Nature Publishing Group
- Year
- 1985
- Tongue
- English
- Weight
- 145 KB
- Volume
- 317
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/317022c0
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Sum ma ry DNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well.
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