DNA studies of X-linked mental retardation associated with a fragile site at Xq27

✍ Scribed by Davies, Kay E. ;Opitz, John M. ;Reynolds, James F.

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 420 KB
• Volume: 23
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.1320230157

✦ Synopsis

Linkage a n a l y s i s i n a f f e c t e d f a m i l i e s i n d i c a t e s a h i g h frequency of recombination around t h i s s i t e i n some f a m i l i e s , a l t h o u g h i n o t h e r s t h e g e n e t i c r e l a t i o n s h i p s a r e q u i t e d i f f e r e n t and c l o s e r l i n k a g e between b r i d g i n g markers i s suggested. The problems a s s o c i a t e d w i t h t h e c l i n i c a l and c y t o g e n e t i c a n a l y s e s of t h i s f a s c i n a t i n g d i s o r d e r a w a i t t h e r e s u l t s of d e t a i l e d m o l e c u l a r approaches.