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Peek-a-boo fragile site at 16d associated with Tourette syndrome, bipolar disorder, autistic disorder, and mental retardation

✍ Scribed by Kerbeshian, Jacob; Severud, Robin; Burd, Larry; Larson, Linda

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 14 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000207)96:1<69::aid-ajmg14>3.0.co;2-5

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✦ Synopsis

Five patients with a fragile site at 16q22-23 and neuropsychiatric disorders are reported. Three of five had Tourette disorder, three had mental retardation, two had bipolar disorder, and one had autistic disorder. During our attempts to study the fragile sites in more detail we were unable to reproduce the fragile sites found several years earlier. The potential relationship between the fragile sites and the neuropsychiatric disorders in these patients is discussed.

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