DNA-strand breaks and rejoining following exposure of synchronized Chinese hamster cells to ionizing radiation
β Scribed by R.M. Humphrey; D.L. Steward; B.A. Sedita
- Book ID
- 118350061
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- English
- Weight
- 404 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0027-5107
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Levels of DNA strand breaks and DNA-protein cross-links (DPCs) were measured using the alkaline elution assay in normal human skin fibroblasts irradiated with 0-200 J m-2 of 254 nm UV radiation and incubated for 0-24 h. On incubation, the yields of both single-strand breaks (SSBs) and DPCs increased
## Abstract In doubleβstrand DNA damage repair, nonhomologous end joining (NHEJ) is more errorβprone than homologous recombination repair (HRR), indicating that the relative prevalence of NHEJ may lead to more incorrect repair and thus to increases in chromosome damage. If DNA damage is extensive a