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DNA sequences of chromosome 21-specific YAC detect the t(8;21) breakpoint of acute myelogenous leukemia

✍ Scribed by Lyndal Kearney; Paul C. Watkins; Bryan D. Young; Nicoletta Sacchi

Book ID: 119104977
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 682 KB
Volume: 57
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(91)90196-2

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## Abstract We compared genomic breakpoints at the __PML__ and __RARA__ loci in 23 patients with therapy‐related acute promyelocytic leukemia (t‐APL) and 25 de novo APL cases.Eighteen of 23 t‐APL cases received the topoisomerase II poison mitoxantrone for their primary disorder. DNA breaks were clu