We have investigated using the DNA binding fluorochromes 7-aminoactinomycin (7-AAMD) and 48,6diamidino-2-phenylindole (DAPI) as cytochemical probes for linker histone (H1)-chromatin interactions in situ. Human lymphocytes, permeabilized with digitonin, were exposed to increasing concentrations of so
DNA sequence specific interactions of histone H1
β Scribed by J. Zlatanova; J. Yaneva
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 312 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0301-4851
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β¦ Synopsis
Histone H1 is know to play a role in the formation and maintenance of higher-order chromatin structure. It has been recently suggested that the linker histone might be also involved in the regulation of the activity of individual genes. If H1 is a regulatory factor in eukaryotic gene transcription, it should possess specificity of binding to defined DNA sequences. This review is an attempt to summarize and discuss the existing literature data on DNA sequence-specific interactions of histone H1.
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