Sequence-selective DNA cleavage by a top
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Kazuhiro Fukasawa; Hideya Komatani; Yoshikazu Hara; Hiroyuki Suda; Akira Okura;
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Article
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1998
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John Wiley and Sons
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French
β 158 KB
An indolocarbazole compound, NB-506, inhibits the activity of topoisomerase I by stabilizing the DNA-topoisomerase I complex (cleavable complex). NB-506 inhibited the religation step of topoisomerase I activity more potently than camptothecin or its derivative, topotecan. A cleavage assay using an e