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DNA replication fidelity: kinetics and thermodynamics

✍ Scribed by M.F. Goodman

Book ID: 113193402
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 852 KB
Volume: 200
Category: Article
ISSN: 0027-5107
DOI: 10.1016/0027-5107(88)90067-x

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## Abstract Balanced pools of deoxyribonucleoside triphosphates (dNTPs) are essential for DNA replication to occur with maximum fidelity. Conditions that create biased dNTP pools stimulate mutagenesis, as well as other phenomena, such as recombination or cell death. In this essay we consider the ef