✦ LIBER ✦

DNA replication fidelity and cancer

✍ Scribed by Bradley D. Preston; Tina M. Albertson; Alan J. Herr

Book ID: 113900486
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 535 KB
Volume: 20
Category: Article
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2010.10.009

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## Abstract Balanced pools of deoxyribonucleoside triphosphates (dNTPs) are essential for DNA replication to occur with maximum fidelity. Conditions that create biased dNTP pools stimulate mutagenesis, as well as other phenomena, such as recombination or cell death. In this essay we consider the ef