DNA repair: the link between primary immunodeficiency and cancer
✍ Scribed by Noel FCC de Miranda; Andrea Björkman; Qiang Pan-Hammarström
- Book ID
- 110108501
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 725 KB
- Volume
- 1246
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
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## Abstract Data from the newly established Immunodeficiency‐Cancer Registry show 151 tumors in 145 patients with primary immunodeficiency syndromes, including: sex‐linked (Bruton's) agammaglobulinemia, 6 patients; severe combined system immunodeficiency, 9 patients; Wiskott‐Aldrich syndrome, 24 pa
Rotation of a DNA nucleotide out of the double helix and into a protein binding pocket (''base flipping'') was first observed in the structure of a DNA methyltransferase. There is now evidence that a variety of proteins, particularly DNA repair enzymes, use base flipping in their interactions with D