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Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping

✍ Scribed by R. Stephen Lloyd; Xiaodong Cheng

Book ID
102650688
Publisher
Wiley (John Wiley & Sons)
Year
1997
Tongue
English
Weight
849 KB
Volume
44
Category
Article
ISSN
0006-3525

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✦ Synopsis

Rotation of a DNA nucleotide out of the double helix and into a protein binding pocket (''base flipping'') was first observed in the structure of a DNA methyltransferase. There is now evidence that a variety of proteins, particularly DNA repair enzymes, use base flipping in their interactions with DNA. Though the mechanisms for base movement into extrahelical positions are still unclear, the focus of this review is how base recognition is modulated by the stringency of binding to the extrahelical base(s) or sugar moiety.

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