DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate
โ Scribed by Martelli, Antonietta; Mattioli, Francesca; Fazio, Stefano; Andrae, Ulrich; Brambilla, Giovanni
- Book ID
- 121879718
- Publisher
- Oxford University Press
- Year
- 1995
- Tongue
- English
- Weight
- 470 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0143-3334
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Previous studies have demonstrated marked differences in the capacity of hepatocytes from rats or hamsters to mediate the metabolic activation of chemical carcinogens to genotoxic (ie, mutagenic) products. Thus far, very few investigations of species differences in DNA repair have been performed. Th
At present, almost all the information on gene-specific DNA repair in mammals comes from studies with transformed cell lines and proliferating primary cells obtained from rodents and humans. In the present study, we measured the repair of specific DNA regions in primary cultures of nondividing rat h