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DNA polymerases in adaptive immunity

✍ Scribed by Weill, Jean-Claude; Reynaud, Claude-Agnès


Book ID
109955852
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
766 KB
Volume
8
Category
Article
ISSN
1474-1741

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## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint